Humans enact the function of PTP-MEG2 in secretory-vesicle fusion with the plasma membrane

Delight and Edmore

Delight and Edmore as PtdIns 3 & 4

 

 

Mr Garikai in full PPE

Mr Garikai in full PPE as PtdIns 5

 

Out of the heat haze

Out of the heat haze

 

Inactive NSF (N-ethylmaleimide-sensitive factor)

Inactive NSF (N-ethylmaleimide-sensitive factor)

 

Inactive NSF (N-ethylmaleimide-sensitive factor)

Inactive NSF (N-ethylmaleimide-sensitive factor)

 

 

Take your positions directs Mr Ramius

 

 

Stone built plasma membrane

Stone built plasma membrane

DSCF3421

 

 

 

The formation of a secretory vesicle

The formation of a secretory vesicle

 

And, finally, the obligatory puppy pic (for Sue)

Hamlet and Brutus

Hamlet and Brutus

 

See WengLong, Joachim, and Hilary – I must have been paying attention at some time!

 

 

 

Rondavel extension part 4: Foundation Walls

Although these look like walls – they are in fact the foundation walls build on top of the footings  i.e. they will be below the level of the final building ground floor.

 

Here is the idea in progress – the foundation walls now part way up.

 

Rondavel extension foundation walls in progress

Rondavel extension foundation walls in progress

 

and here, showing a temporary retaining wall in stone immediately behind the builders

Rondavel extension foundation walls in progress

Rondavel extension foundation walls in progress

 

Next some details of the building process when working in stone as we are here.

 

Farai begins his wall

Farai begins his wall

 

Of course the stones don’t come in  pre-packed sizes…so yes they have to be first burnt, then hammered and finally, artfully positioned so that they fit and the ‘look’ from the outside or inside is ‘good’

Hammering stone to size

Hammering stone to size

 

 

Mr Patrick Samhembere in action

Mr Patrick Samhembere in action

Mr Patrick Samhembere in action

Mr Patrick Samhembere in action

 

Mr Patrick Samhembere in action

Mr Patrick Samhembere in action

The hands that built Hornbydale

The hands that built Hornbydale

 

The hands that built Hornbydale

The hands that built Hornbydale

 

 

After a day the spare cement is scraped away

After a day the spare cement is scraped away

 

Mr Perkins Makore

Mr Perkins Makore – builders assistant

 

Mr Farai Samhembere - builder

Mr Farai Samhembere – builder

 

Mr Farai Samhembere - builder

Mr Farai Samhembere – builder

Mr Mabika - builder

Mr Mabika – builder

 

Mr Tendai Mushonga - builders assistant

Mr Tendai Mushonga – builders assistant

 

Mr Tendai Samhembere - builder

Mr Tendai Samhembere – builder

 

Mr Tendai Samhembere - builder

Mr Tendai Samhembere – builder

 

Nearly there on the foundation wall

Nearly there on the foundation wall

Finished section of foundation wall

Finished section of foundation wall

 

 

Tendai enjoying having his picture taken!

Tendai enjoying having his picture taken!

 

Update:

 

The completed  ‘slab’ on top of the foundation walls

Completed slab on top of foundation walls

Completed slab on top of foundation walls – looking west

 

Completed slab on top of foundation walls

Completed slab on top of foundation walls – looking east

Tadpole Part 7: The Before & The After

Here are some ‘before’ and ‘after’ shots – so we can see how far we’ve come since 1st April 2014!

 

At the beginning –  a burnt out shell of a building

A burnt out roofless structure

A burnt out roofless structure

 

and suddenly ..

The tadpole building

The tadpole building

 

 

Walls go up and extend the original rondavel

Walls go up and extend the original rondavel

Looks better now

Looks better now

 

looking south

looking south

 

at sunset now

at sunset now

 

the original doorway

the original doorway

and now its an interior doorway!

and now its an interior doorway!

And again from the inside – the original door and window to its left.

that original doorway from the inside

that original doorway from the inside

 

our masonry stove - faced in soap stone

our masonry stove – faced in soap stone

Remember the saga of the stairs:

Mr Willard infront of the eventual stairs

Mr Willard infront of the eventual stairs

 

Well we got there in the end!

stairs - unfinished

stairs – unfinished

Finished stairs

Finished stairs

 

Looking down those stairs

Looking down those stairs

And finally the school room up those stairs

 

Montessori school room upstairs in Tadpole

Our Montessori school room upstairs in Tadpole

 

The Scottish play in our school library

The Scottish play in our school library

 

Moon shot from the southern hemisphere

Dramatic pictures are emerging of a new space mission apparently targeted at the moon. At the secret high-altitude launch site our cameras have exclusive access to the new rocket system as it is being developed.

The lunch site has been chosen so that the rocket is carefully aimed at the moon from lift off onwards.
Aiming at the moon

Aiming at the moon

Here we see the all important nose cone developing against a backdrop of distant peaks and troughs
Nose cone

Nose cone

As engineering continues to work on last minute adjustments to the crew capsule …
Engineering in the Main Cabin

Engineering in the Main Cabin

… the crew takes a moment to relax on the newly built launch tower during the rigorous training and selection procedures Happy crew on the launch tower

Happy crew on the launch tower

We are told that moon juice will be collected via this retractable arm – now being re-programmed for low gravity cheese. The amount of R.AN.DEE (Ranting All Night & Day Endlessly) that has gone into this new exploration system is sure to excite fellow space-fans – it is clearly in-excess of anything seen before in such a mission.
Retractable arm

Retractable arm

The crew decide they want to see where they are going so aerodynamic potholes are added to the cabin
Portholes to aid navigation in space

Portholes to aid navigation in space

An early morning test firing of the rockets leaves no doubt as to the tremendous cheese-melting thrust the newly developed power system will generate
Cheese melting thrust

Cheese melting thrust

Now all we need to know is whose shirts they will wear….

The Tadpole Building: Part 2 – Utilities

Tadpole after plastering the outside

Tadpole after plastering the outside

View from the septic tank

View from the septic tank

Routes were chipped out of the brickwork for the electrical conduits prior to plastering the interior. (No nice cavity walls here)

Routes of electrical conduits

Routes of electrical conduits

The electricians covered in brick dust

The electricians covered in brick-dust

Brick dust

Brick-dust

Next Mr Patrick 2 ‘plasters’ (with cement)  the exterior and interior. Chicken wire was used to add strength to the outside of the existing round rondavel.

Mr Patrick 2 plastering

Mr Patrick 2 plastering

Mr Tadoka and Mr Paul the plumbers chipped out the shower

DSCN7765

Place for the shower

And finally the most important part of any building and the one you have been waiting for … the septic tank.

Here being inspected by ‘Mr Huckle’

'Mr Huckle' at the septic tank

‘Mr Huckle’ at the septic tank

Mr Farai plastering the septic tank

Mr Farai plastering the septic tank

The plumbers had to spend a couple of extra days burning a route through the stones for the pipe connecting waste pipe

Burning rocks in the trench

Burning rocks in the trench

Mr Tendai looking safer than usual!

Mr Tendai in hard hat

Mr Tendai in hard hat